One cool thing I have noticed with Genesis is the ability to choose your Page Layout for each post and page, this will also work for your products you just need to add the product post type support
Adding the Post Type Support.
If your using a Genesis child theme (recommended if you customizing your theme otherwise changes will be lost if you update the framework)
Simply copy and paste this function below into your themes functions.php file.
add_action(‘init’ , ‘wpec_genesis_add_layout_support’);
add_post_type_support( ‘wpsc-product’, ‘genesis-layouts’ );
Save you file, clear your cache and next time you go to create a product you will see Genesis layout support has now been added.